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KMID : 0379919900150010033
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Journal of The Korea Socity of Health Informatics and Statistics
1990 Volume.15 No. 1 p.33 ~ p.46
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Review of statistical methods in long - term rerm rodent tests for detecting carcinogens and in the Salmonella mutagenicity assay for the screening procedure
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Abstract
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We introduce the procedure of the long-term rodent test conducted to detect carcinogens among chemicals in the National Toxicology Program, U.S.Department of Health and Human Services since 1970´s We´ll illustrate that the detection of carcinogens if eventuallystatistical tests of several hypotheses. We cite actual experimental results of D&C Red No.9(NTP TR-225) and Glycide(NTP TR-374) for the illustration.
Several weakpoints of the long-term rodent tests encouraged the development of various short-term tests hopefully as a surrogate of the long-term tests. Among them Ames Salmonella mutagenicity(SAL) test if the most popular. Empirical evidence on SAI, test indicates that it can be used as a screening procedure for selecting chemicals for the long-term rodent experiment.]
We give a brief introduction of the biological background of the SAL test and then introduce the standard protocol of the SAL test. We will review two statistical models of the dose-response curve of the SAL test data. We show that mutagenicity test turns out to be the significance test of the initial slope of the dose-response curve. Finally. we suggest two problems for the further study.
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